Research Progress on DKK1 Gene in Leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1190-1193, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-274068
ABSTRACT
A number of studies have demonstrated that the methylation of Dickkopf-1 (DKK1) gene promoter is related with the occurrence and development of many neoplastic diseases. By means of binding with corresponding receptors, DKK1 blocks the transduction pathway of Wnt/β-catenin/TCF and inhibits the proliferation and invasion of tumor cells, inducing apoptosis. Leukemia is a hyperplastic disease of hematopoietic stem cell malignant clone. Its pathogenesis has been confirmed to be closely related with the aberrant activation of Wnt signaling pathway. This pathway is associated with the self-renewal and proliferation of the hematopoietic stem cells, which can regulate growth, differentiation, migration of the cells, angiogenesis and embryonic development. Its expression is regulated by some suppressor genes like Dickkopf 1 (DKK1). Leukemia often accompanied by methylation modification of the DKK1 gene, so as to leads to silencing itself and activation of the Wnt signaling pathway, which cause the occurrence of leukemia. Some therapeutic methods on leukemia aiming at DKK1 gene have been reported, among which DKK1 gene was demethylated. The intensive study on the expression and function of DKK1 should be important for the early diagnosis, treatment and prognosis. This article reviews the current progress in this field.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Leucemia
/
Regulación Leucémica de la Expresión Génica
/
Diferenciación Celular
/
Apoptosis
/
Péptidos y Proteínas de Señalización Intercelular
/
Proteínas Wnt
/
Beta Catenina
/
Vía de Señalización Wnt
Tipo de estudio:
Estudio pronóstico
/
Estudio de tamizaje
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2015
Tipo del documento:
Artículo
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