Meta-analysis of oral squamous cell carcinoma on gene expression level / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the differently expressed genes of oral squamous cell carcinoma (OSCC) tissue.</p><p><b>METHODS</b>Gene expression datasets related to oral squamous cell carcinoma in the gene expression omnibus (gene expression omnibus, GEO) repository were retrieved. Datasets were merged by normalization.Significantly expressed genes were obtained by statistical methods, and genes' functions, interactions, signaling pathways were analyzed accordingly.</p><p><b>RESULTS</b>In GEO, there were 1 125 records related to OSCC, and four of them were selected and merged to a super array data, within the super array data, 233 genes were significantly expressed (P < 0.05) , and the top 100 significantly expressed genes were selected as signature genes.Signature genes were more related to cell surface or cell-cell interactive activities. Clusters of interactive signature genes and the related signaling pathways were related with mitosis process.</p><p><b>CONCLUSIONS</b>OSCC signature genes and the corresponding signaling pathways will provide not only an important clue for further research of the disease, but also reference for diagnosis and treatment.</p>