Association between urinary 8-OHdG and pulse wave velocity in hypertensive patients with type 2 diabetes mellitus
Singapore medical journal
;
: 202-208, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-274256
ABSTRACT
<p><b>INTRODUCTION</b>Oxidative stress, assessed using 8-hydroxy-2'-deoxyguanosine (8-OHdG), can be associated with arterial stiffness in patients with type 2 diabetes mellitus (T2DM) and/or hypertension (HT). We investigated the correlation between urinary 8-OHdG and pulse wave velocity (PWV) in hypertensive and non-hypertensive T2DM patients with fair glycaemic control to determine the clinical significance of HT as a comorbidity in the diabetic state.</p><p><b>METHODS</b>Clinical data, including traditional cardiovascular risk factors, diabetic complications, prescribed agents, urinary 8-OHdG level and brachial-ankle PWV, was collected from T2DM patients with and without HT.</p><p><b>RESULTS</b>There were 76 patients (45 men, 31 women; mean age 61 years; mean haemoglobin A1c level 6.5%) in the study cohort. T2DM patients with HT had significantly higher mean PWV than patients without HT (1,597 cm/s vs 1,442 cm/s; p < 0.05). Patients with HT showed no significant difference in 8-OHdG levels relative to those without HT (median 7.9 ng/mg creatinine vs 8.8 ng/mg creatinine; p > 0.05). Simple linear correlation and stepwise multiple linear regression analyses revealed that 8-OHdG levels correlated independently, significantly and positively with PWV among T2DM patients with HT (r = 0.33, p < 0.05; β= 0.23, p < 0.05). No significant correlation was observed between 8-OHdG levels and PWV among T2DM patients without HT.</p><p><b>CONCLUSION</b>In the hypertensive state, oxidative stress can be responsible for the development of arterial stiffness, even in patients with fairly well controlled T2DM. Oxidative stress management may be necessary for the prevention of cardiovascular disease in this population.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Orina
/
Hemoglobina Glucada
/
Estudios de Cohortes
/
Estrés Oxidativo
/
Complicaciones de la Diabetes
/
Desoxiguanosina
/
Diabetes Mellitus Tipo 2
/
Índice Tobillo Braquial
/
Rigidez Vascular
/
Análisis de la Onda del Pulso
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Singapore medical journal
Año:
2014
Tipo del documento:
Artículo
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