Experimental study on inhibitory effect of GFW on transplantable tumor cell metastasis in S180 tumor-bearing mices / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To detect the effect of GFW on tumor cell metastasis in S180 tumor-bearing mice.</p><p><b>METHOD</b>S180 tumor-bearing mice model were replicated and divided randomly into 4 groups the model group, the GFW group, the cyclophosphamide group and the combination administration group. VEGF in serum on each group was detected by ELISA, and the expression of metastasis suppressor gene nm23H1 and cell adhesion molecule CD44 in Sarcoma were detected by SABC immunohistochemical assay.</p><p><b>RESULT</b>Compared with the model group, the GFW group showed a significant decrease in VEGF in serum (P < 0.01). From their statistically significant difference, GFW was proved to promote the expression of metastasis suppressor gene nm23H1 and inhibit the expression of cell adhesion molecule CD44 (P < 0.05).</p><p><b>CONCLUSION</b>GFW has an effect on inhibiting tumor metastasis to some extent.</p>