Protective effect of salvianolic acid B on isolated heart ischemia/reperfusion injury in rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 358-361, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-274343
ABSTRACT
<p><b>OBJECTIVE</b>To study the protective effect and mechanism of salvianolic acid B on isolated heart ischemia/reperfusion injury in rats.</p><p><b>METHOD</b>Forty-eight SD rats were divided into 6 groups randomly(n = 8) the control group, the positive administration group (verapamil 150 microg x L(-1)), and high, middle and low-dose salvianolic acid B groups (10, 5, 2.5 mg x L(-1)). The myocardial ischemia/reperfusion injury model was established using the Langendorff method, re-perusing isolated working hearts for 30 min after ischemia for 25 min. A water-bag catheter was inserted in rat left atrium for recording the effect of salvianolic acid B on hemodynamics indexes-AST, LDH, SOD and MDA.</p><p><b>RESULT</b>Various group with different doses showed that salvianolic acid B decreased AST, release of LDH and formation of MDA and increased SOD activity.</p><p><b>CONCLUSION</b>Salvianolic acid B showed a protective effect on myocardial ischemia/reperfusion injury. Its mechanism may be related with improvement of cardiac contractility, cleaning of oxygen free radicals and reduction of lipid peroxidation.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Superóxido Dismutasa
/
Factores de Tiempo
/
Benzofuranos
/
Técnicas In Vitro
/
Medicamentos Herbarios Chinos
/
Daño por Reperfusión Miocárdica
/
Ratas Sprague-Dawley
/
Hemodinámica
/
L-Lactato Deshidrogenasa
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2012
Tipo del documento:
Artículo
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