Progress in the fragment-based drug discovery / 药学学报
Acta Pharmaceutica Sinica
;
(12): 14-24, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-274596
ABSTRACT
As an extension of the structure-based drug discovery, fragment-based drug discovery is matured increasingly, and plays an important role in drug development. Fragments in a small library, with lower molecular mass and high "ligand efficiency", are detected by SPR, MS, NMR, X-ray crystallography technologies and other biophysical methods. Then they are considered as starting points for chemical optimization with the guidance of structural biology methods to get good "drug-like" lead and candidate compounds. In this article, we reviewed the current progress of fragment-based drug discovery and detailed a number of examples to illustrate the novel strategies.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fragmentos de Péptidos
/
Conformación Proteica
/
Espectroscopía de Resonancia Magnética
/
Química
/
Diseño Asistido por Computadora
/
Cristalografía por Rayos X
/
Resonancia por Plasmón de Superficie
/
Bibliotecas de Moléculas Pequeñas
/
Descubrimiento de Drogas
/
Ligandos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2013
Tipo del documento:
Artículo
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