Design, synthesis and antitumor activity of sorafenib analogues containing 2-picolinylhydrazide moiety / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1623-1629, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-274612
ABSTRACT
A novel series of sorafenib analogs containing 2-picolinyl hydrazide moiety were designed and synthesized. In vitro, most of synthesized compounds have antiproliferation activity on MDA-MB-231, ACHN, HepG2, Mia-PaCa-2 and SW1990 cell lines tested by MTT assay. It is worth noting that the antitumor activities of compounds 2c, 2d and 2f are more potent than that of sorafenib on pancreatic cancer cells Mia-PaCa-2 and SW1990, and the activities of compounds 3f and 3g are 2-3 times than that of sorafenib on human hepatocellular carcinoma HepG2 cell line.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Compuestos de Fenilurea
/
Relación Estructura-Actividad
/
Ensayos de Selección de Medicamentos Antitumorales
/
Diseño de Fármacos
/
Estructura Molecular
/
Química
/
Niacinamida
/
Línea Celular Tumoral
/
Proliferación Celular
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2012
Tipo del documento:
Artículo
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