TREK1 potassium channels and depression / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1403-1408, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-274646
ABSTRACT
Major depression disorder is an increasing heavy burden in modem society, but its pathological mechanism is still vague. Recent evidence indicated that two pore potassium channel, TREK1, is one of the important drug targets of antidepressants. The structural and functional research progress of TREK1 potassium channel were reviewed with an emphasis on its roles in anti-depression, neuronal protection, and neuronal plasticity. The complicated interactions between TREK1 potassium channel and monoamine transmitters-receptors were also reviewed and future directions to explore the underline mechanism were also discussed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fisiología
/
Polimorfismo Genético
/
Serotonina
/
Receptores de Serotonina
/
Sistemas de Liberación de Medicamentos
/
Canales de Potasio de Dominio Poro en Tándem
/
Receptores de Serotonina 5-HT4
/
Trastorno Depresivo Mayor
/
Técnicas de Inactivación de Genes
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2012
Tipo del documento:
Artículo
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