TREK1 potassium channels and depression / 药学学报
Acta Pharmaceutica Sinica
; (12): 1403-1408, 2012.
Article
en Zh
| WPRIM
| ID: wpr-274646
Biblioteca responsable:
WPRO
ABSTRACT
Major depression disorder is an increasing heavy burden in modem society, but its pathological mechanism is still vague. Recent evidence indicated that two pore potassium channel, TREK1, is one of the important drug targets of antidepressants. The structural and functional research progress of TREK1 potassium channel were reviewed with an emphasis on its roles in anti-depression, neuronal protection, and neuronal plasticity. The complicated interactions between TREK1 potassium channel and monoamine transmitters-receptors were also reviewed and future directions to explore the underline mechanism were also discussed.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Farmacología
/
Fisiología
/
Polimorfismo Genético
/
Serotonina
/
Receptores de Serotonina
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Sistemas de Liberación de Medicamentos
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Canales de Potasio de Dominio Poro en Tándem
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Receptores de Serotonina 5-HT4
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Trastorno Depresivo Mayor
/
Técnicas de Inactivación de Genes
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2012
Tipo del documento:
Article