Synthesis and antitumor activity of novel 2-(1-substituted-piperidin-4-ylamino)quinazolines as antitumor agents / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1164-1178, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-274682
ABSTRACT
A variety of novel 2-(1-substituted-piperidine-4-ylamino)quinazoline derivatives were prepared and their antiproliferative activities on five cancer cell lines were evaluated by MTT assay. Quinazolines 4j-4l, 5a, 5b and 5d bearing a small hydrophobic alkyl group on piperidine ring exhibited potent antitumor activities with IC50 values at micromolar level. Compound 41 displayed significant in vivo antitumor activity with 72.9% inhibition on H22 tumor growth and 80% inhibition on Lewis lung cancer growth at a dose of 200 mg x kg(-1).
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Quinazolinas
/
Ensayos de Selección de Medicamentos Antitumorales
/
Química
/
Carcinoma Pulmonar de Lewis
/
Concentración 50 Inhibidora
/
Línea Celular Tumoral
/
Neoplasias Hepáticas
/
Ratones Endogámicos C57BL
Límite:
Animales
Idioma:
Inglés
Revista:
Acta Pharmaceutica Sinica
Año:
2012
Tipo del documento:
Artículo
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