Establishment of drug screening assay and pharmacodynamic evaluation method targeting influenza RNA polymerase / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1159-1163, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-274683
ABSTRACT
Influenza virus RNA-dependent RNA polymerase (RdRP) is essential for replication and expression of influenza virus genome. Viral genomic sequences encoding RdRP are highly conservative, thus making it a potential anti-influenza drug target. A cell-based influenza RdRP inhibitor screening assay was established by a luciferase reporter system to analyze the activity of RdRP. Specificity study and statistic analysis showed that the screening assay is sensitive and reproducible.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Antivirales
/
Farmacología
/
Plásmidos
/
Ribavirina
/
ARN Polimerasa Dependiente del ARN
/
Transfección
/
Amantadina
/
Reproducibilidad de los Resultados
/
Sensibilidad y Especificidad
/
Genes Reporteros
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2012
Tipo del documento:
Artículo
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