Efficacy of catheter-based renal denervation in mongrel neurogenic hypertensive dogs / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 14-17, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-275115
ABSTRACT
<p><b>OBJECTIVE</b>Hypertension is the most common risk factor for cardiovascular diseases and stroke. Renal sympathetic hyperactivity is associated with hypertension. The aim of this study was to explore the efficacy of renal denervation for hypertension.</p><p><b>METHODS</b>Eighteen mongrel neurogenic hypertensive dogs were divided into intervention [mean arterial pressure (150.6 ± 18.8) mm Hg (1 mm Hg = 0.133 kPa) plus renal sympathetic denervation by percutaneous catheter-based radiofrequency, n = 10] and control [mean arterial pressure (147.4 ± 13.2) mm Hg, n = 8] group. Mean arterial pressure before and at 2, 4, 6 and 10 weeks after procedure was invasively measured. Renin activity (PRA), angiotensin II (AngII), aldosterone (Ald), and creatinine (Cr) were detected at 2, 6 and 10 weeks after procedure.</p><p><b>RESULTS</b>Mean arterial pressure remained unchanged in control group. In intervention group, mean arterial pressure (MAP) decreased to (130.4 ± 14.1) mm Hg, (136.2 ± 17.1) mm Hg, (128.7 ± 14.7) mm Hg and (126.1 ± 12.7) mm Hg respectively at 2, 4, 6, and 10 weeks after procedure. Meanwhile, the level of PRA, AngII, Ald significantly reduced post procedure compared with pre-procedural level (P < 0.05) and the Cr level remained unchanged post procedure (P > 0.05).</p><p><b>CONCLUSION</b>Sympathetic nervous system plays an important role in the progression of hypertension. Catheter-based renal denervation results in substantial and sustained blood-pressure reduction in this model.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Cirugía General
/
Simpatectomía
/
Ablación por Catéter
/
Hipertensión
/
Riñón
/
Métodos
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Cardiology
Año:
2012
Tipo del documento:
Artículo
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