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Research progress in co-delivery of gene and chemotherapy drugs with cationic liposome carrier for cancer therapy / 药学学报
Acta Pharmaceutica Sinica ; (12): 986-992, 2012.
Artículo en Chino | WPRIM | ID: wpr-276211
ABSTRACT
Despite recent advances in conventional therapeutic approaches for cancer, the efficacy of chemotherapy for cancer is limited due to the drug resistance and toxic side effects during treatment. To overcome drug resistance, higher doses of the toxic chemotherapy drugs are frequently administered, thus leading to even severe adverse side effects, which have limited their clinical application. Cationic liposome as a novel non-viral carrier for co-delivery of gene and chemotherapy drugs in cancer gene therapy has already attracted more and more attention in recent years. Most importantly, this combined strategy can generate a significant synergistic effect, which can silence the related gene expression and increase the concentration of the intracellular chemotherapy drugs. This approach allows the use of a much lower dose of the chemotherapy drugs to achieve same therapeutic effect, which may have the potential for overcoming some major limitations of the conventional chemotherapy. In conclusion, co-delivery of gene and chemotherapy drugs with cationic liposome delivery system will play a vital role in the future and especially could be a promising clinical treatment for drug-resistant tumors.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Terapéutica / ADN / Portadores de Fármacos / Terapia Genética / Protocolos de Quimioterapia Combinada Antineoplásica / Cationes / Química / Sistemas de Liberación de Medicamentos / Técnicas de Transferencia de Gen / ARN Interferente Pequeño Límite: Animales / Humanos Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Terapéutica / ADN / Portadores de Fármacos / Terapia Genética / Protocolos de Quimioterapia Combinada Antineoplásica / Cationes / Química / Sistemas de Liberación de Medicamentos / Técnicas de Transferencia de Gen / ARN Interferente Pequeño Límite: Animales / Humanos Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2012 Tipo del documento: Artículo