Immunoregulatory effect of artesunate on allergic contact dermatitis and its mechanism / 药学学报
Acta Pharmaceutica Sinica
;
(12): 884-889, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-276228
ABSTRACT
This study is to elucidate the immunoregulation mechanisms of artesunate (AST) on allergic contact dermatitis (ACD). Pharmacodynamics analyses, HE staining, semi-quantitative RT-PCR and Western blotting were used to explore the effects of AST on the related cytokines, transcription factor and signaling molecule of ACD respectively. The results indicated that topical administration of AST not only reduced the increase of ear swelling, spleen index and inflammatory cells infiltration in ACD mice, but also inhibited remarkably the expression of IFN-gamma, T-bet and NF-kappaB p65. It's suggested that AST could exhibit suppressive effects on inflammatory response and immune function of ACD, which indicates the possibility of developing AST as a novel immunoregulatory agent in the treatment of ACD and other immune-related diseases.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
ARN Mensajero
/
Estructura Molecular
/
Química
/
Administración Tópica
/
FN-kappa B
/
Interleucina-4
/
Interferón gamma
/
Dermatitis Alérgica por Contacto
Límite:
Animales
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2012
Tipo del documento:
Artículo
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