Advance in the study of targeting delivery system for siRNA mediated by aptamers / 药学学报
Acta Pharmaceutica Sinica
;
(12): 850-855, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-276233
ABSTRACT
RNA interference (RNAi), as a new technology of gene therapy, has been used in the studies of many diseases in vitro, however, targeting delivery of small interference RNA (siRNA) is still a bottleneck for clinical therapy of siRNA agents. Aptamer is a group of oligonucleotides with high affinity and targeting, and is becoming another important means of delivery for siRNA. In this review, we summarized siRNA delivery obstacles in vivo and recent attractive developments increatively using cell-internalizing aptamers to deliver siRNAs to target cells.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Terapéutica
/
Sistemas de Liberación de Medicamentos
/
ARN Interferente Pequeño
/
Interferencia de ARN
/
Aptámeros de Nucleótidos
/
Técnica SELEX de Producción de Aptámeros
/
Metabolismo
/
Métodos
/
Neoplasias
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2012
Tipo del documento:
Artículo
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