Qualitative and quantitative analysis of fluoxetine hydrochloride by 19F NMR / 药学学报
Acta Pharmaceutica Sinica
;
(12): 630-633, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-276268
ABSTRACT
The chemical shift of fluoxetine hydrochloride appears at delta 14.15 in 19F NMR analysis. The delta moved upfield slightly from 14.158 to 14.145 when the concentration of solution became diluted from 2.00 to 0.05 mmol x L(-1). Spiking test was suggested to confirm the existence of the compound for qualitative analysis. 19F NMR detection sensitivity test illustrated that a concentration of 17 mg in 1 L water could be detected while the sample was scanned 500 times with optimum parameters. In quantitative analysis, standard curve of concentration versus fluorine signal intensity was proposed to determine the amount of fluoxetine. Long capillary tube containing trifluoroacetic acid was used as internal standard for the integration measurements and straight line was obtained with good fitting. Direct additions of trifluoroethanol to fluoxetine solutions gave a poorer standard curve.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ácido Trifluoroacético
/
Espectroscopía de Resonancia Magnética
/
Estructura Molecular
/
Química
/
Fluoxetina
/
Flúor
Tipo de estudio:
Investigación cualitativa
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2012
Tipo del documento:
Artículo
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