A novel C27-steroidal glycoside sulfate from Liriope graminifolia / 药学学报
Acta Pharmaceutica Sinica
;
(12): 619-623, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-276270
ABSTRACT
An unusual novel C27-steroidal glycoside sulfate was isolated from the underground organs of Liriope graminifolia (Linn.) Baker with three known compounds. Their chemical structures were determined by spectral analysis, including HR-MS, 1D and 2D NMR as (25S)-ruscogenin 1-sulfate-3-O-alpha-L-rhamnopyranoside (1), (25S)-ruscogenin 1-O-beta-D-xylopyranosyl-3-O-alpha-L-rhamnopyranoside (2), hesperidin (3), and 4', 7-dihydroxy-5-methoxyflavanone (4). Compound 1 has cytotoxic activities against K562 and HL60 cells with IC50 values of 18.6 microg x mL(-1) and 16.5 microg x mL(-1), respectively.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Plantas Medicinales
/
Espirostanos
/
Medicamentos Herbarios Chinos
/
Química
/
Células HL-60
/
Células K562
/
Concentración 50 Inhibidora
/
Liriope (Planta)
/
Tubérculos de la Planta
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2012
Tipo del documento:
Artículo
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