Neuroprotective effect of longistyline A against corticosterone-induced neurotoxicity in PC12 cells / 药学学报
Acta Pharmaceutica Sinica
;
(12): 600-603, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-276274
ABSTRACT
This study is to investigate the protective effect of longistyline A against corticosterone-induced neurotoxicity in PC12 cells. While PC12 cells were exposed to 100 micromol x L(-1) corticosterone for 48 h, cell survival rate was reduced and lactate dehydrogenase (LDH) release increased. In parallel, corticosterone caused significant elevations of DNA fragmentation, [Ca2+]i and caspase-3 activity. However, when the PC12 cells were incubated with longistyline A (4.0, 8.0 and 16.0 micromol x L(-1)) in the presence of 100 micromol x L(-1) corticosterone for 48 h, the effects were evidently alleviated, but dose-dependent manner was not obvious. In summary, longistyline A could generate a neuroprotective effect against corticosterone-induced neurotoxicity in PC12 cells possibly by decreasing [Ca2+]i and caspase-3 activity.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fenoles
/
Plantas Medicinales
/
Corticosterona
/
Estructura Molecular
/
Supervivencia Celular
/
Química
/
Calcio
/
Células PC12
/
Hojas de la Planta
Límite:
Animales
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2012
Tipo del documento:
Artículo
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