Alu and L1 Retroelements Are Correlated with the Tissue Extent and Peak Rate of Gene Expression, Respectively
Journal of Korean Medical Science
;
: 783-792, 2004.
Artículo
en Inglés
| WPRIM
| ID: wpr-27635
ABSTRACT
We exploited the serial analysis of gene expression (SAGE) libraries and human genome database in silico to correlate the breadth of expression (BOE; housekeep-ing versus tissue-specific genes) and peak rate of expression (PRE; high versus low expressed genes) with the density distribution of the retroelements. The BOE status is linearly associated with the density of the sense Alus along the 100 kb nucleotides region upstream of a gene, whereas the PRE status is inversely correlated with the density of antisense L1s within a gene and in the up- and downstream regions of the 0-10 kb nucleotides. The radial distance of intranuclear position, which is known to serve as the global domain for transcription regulation, is reciprocally correlated with the fractions of Alu (toward the nuclear center) and L1 (toward the nuclear edge) elements in each chromosome. We propose that the BOE and PRE statuses are related to the reciprocal distribution of Alu and L1 elements that formulate local and global expression domains.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Estudio Comparativo
/
Distribución Tisular
/
Genoma Humano
/
Regulación de la Expresión Génica
/
Mapeo Cromosómico
/
Análisis de Secuencia de ADN
/
Retroelementos
/
Estadística
/
Elementos de Nucleótido Esparcido Largo
/
Elementos Alu
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
2004
Tipo del documento:
Artículo
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