BRCA1/2 associated hereditary breast cancer / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 85-89, 2008.
Artículo
en Inglés
| WPRIM
| ID: wpr-277297
ABSTRACT
Breast cancer is one of the leading causes of death in women today. Some of the patients are hereditary, with a large proportion characterized by mutation in BRCA1 and/or BRCA2 genes. In this review, we provide an overview of these two genes, focusing on their relationship with hereditary breast cancers. BRCA1/2 associated hereditary breast cancers have unique features that differ from the general breast cancers, including alterations in cellular molecules, pathological bases, biological behavior, and a different prevention strategy. But the outcome of BRCA1/2 associated hereditary breast cancers still remains controversial; further studies are needed to elucidate the nature of BRCA1/2 associated hereditary breast cancers.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Pronóstico
/
Neoplasias de la Mama
/
Regulación Neoplásica de la Expresión Génica
/
Progresión de la Enfermedad
/
Proteína BRCA1
/
Predisposición Genética a la Enfermedad
/
Proteína BRCA2
/
Proteínas Reguladoras de la Apoptosis
/
Genética
Tipo de estudio:
Estudio pronóstico
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Journal of Zhejiang University. Science. B
Año:
2008
Tipo del documento:
Artículo
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