Analysis on the decline of hepatitis C virus RNA in the blood using a mathematical model / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 886-888, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-277649
ABSTRACT
<p><b>OBJECTIVE</b>To establish a mathematical model of hepatitis C virus (HCV) replication and develop a working theory for antiviral therapy in order to understand the dynamics of HCV replication.</p><p><b>METHODS</b>Peripheral blood cells of 4 hepatitis C patients were cultured. Quantities of the HCV were detected every 15 min by real-time PCR. The data were analyzed using SPSS software. A mathematical functional relationship between HCV RNA and the time lapse was established.</p><p><b>RESULTS</b>The quantity of HCV RNA declined and it fell into a mathematical model Y=3E+0.8e(-0.5467x) (r=0.9547). The estimated virion half-life was 45 min on the average.</p><p><b>CONCLUSIONS</b>The decline of HCV RNA in the blood is not of a linear trend and the HCV RNA lasts a longer time although the speed of the decline is faster than that in vivo.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Virología
/
Replicación Viral
/
Sangre
/
ARN Viral
/
Dinámicas no Lineales
/
Hepacivirus
/
Carga Viral
/
Hepatitis C Crónica
/
Semivida
/
Modelos Teóricos
Límite:
Adulto
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Hepatology
Año:
2007
Tipo del documento:
Artículo
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