Action and resistance mechanisms of capreomycin: a functional genomic perspective / 药学学报
Acta Pharmaceutica Sinica
;
(12): 788-792, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-277776
ABSTRACT
Last two decades have witnessed the resurging of tuberculosis (TB) and multi-drug resistant TB, even the extensive drug resistant TB. It is urgent to develop novel drug to combat the increasingly worsen TB. Capreomycin is an ideal second-line TB drug. It is also recognized as an attractive template to develop more peptide antibiotics. In this review, the biosynthesis gene cluster of capreomycin, the action mechanism unveiled by transcriptome and novel resistance rational are summarized from the recent functional genomic investigation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Proteínas Ribosómicas
/
Capreomicina
/
Química
/
Sistemas de Lectura Abierta
/
Tuberculosis Resistente a Múltiples Medicamentos
/
Farmacorresistencia Bacteriana Múltiple
/
Quimioterapia
/
Genes Bacterianos
/
Genética
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2008
Tipo del documento:
Artículo
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