Progress in small-molecule inhibitors of Bcl-2 family proteins / 药学学报
Acta Pharmaceutica Sinica
;
(12): 669-677, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-277814
ABSTRACT
Apoptosis is an essential factor in keeping homeostasis of the organism. Apoptosis is regulated by a series of cytokines. Bcl-2 family proteins are key regulators of apoptosis. The Bcl-2 family includes both anti- and pro-apoptotic proteins with opposing biological functions. Their interaction regulates the transmission of the apoptosis signal. High expression of anti-apoptotic members such as Bcl-2 and Bcl-xL are commonly found in human cancers. In recent years, following the disclosing of the crystal structures of Bcl-2 family proteins, researchers have paid attention to the development of the small molecule inhibitors of Bcl-2 family proteins. This article reviews the progress in this field from the view of drug design.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Piperazinas
/
Relación Estructura-Actividad
/
Sulfonamidas
/
Tiazoles
/
Benzopiranos
/
Compuestos de Bifenilo
/
Gosipol
/
Medicamentos Herbarios Chinos
/
Diseño de Fármacos
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2008
Tipo del documento:
Artículo
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