Signal transduction by protein tyrosine kinases and antitumor agents / 药学学报
Acta Pharmaceutica Sinica
;
(12): 323-334, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-277853
ABSTRACT
Intracellular signal transduction plays an important role in the process of cellular metabolism, segmentation, differentiation, biological behaviour and cell death. Overactive signal transduction relates to tumor development and progression. Signaling pathways operated by protein tyrosine kinases (PTKs) will be illuminated here briefly. The Ras/Raf/MAPK and PI-3K/Akt pathways through receptor protein tyrosine kinases (RTKs), the Src, Bcr-Abl and JAK/STAT pathways by non-receptor protein tyrosine kinases (nrPTKs) are shown separately. Antitumor agents targeting the key proteins involved in the above five signalling routes are also summarized in this review.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Proteínas Tirosina Quinasas
/
Transducción de Señal
/
Proteínas Tirosina Quinasas Receptoras
/
Proteínas ras
/
Familia-src Quinasas
/
Fosfatidilinositol 3-Quinasas
/
Factores de Transcripción STAT
/
Metabolismo
/
Antineoplásicos
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2008
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS