Advances in the Relationship between Adipokines and β-cell Failure in Type 2 Diabetes Mellitus / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 601-606, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-277933
ABSTRACT
β-cell failure coupled with insulin resistance plays a key role in the development of type 2 diabetes mellitus (T2DM). Changed adipokines in circulating level form a remarkable link between obesity and both β-cell failure and insulin resistance. Some adipokines have beneficial effects,whereas others have detrimental properties. The overall contribution of adipokines to β-cell failure mainly depends on the interactions among adipokines. This article reviews the role of individual adipokines such as leptin,adiponectin,and resistin in the function,proliferation,death,and failure of β-cells. Future studies focusing on the combined effects of adipokines on β-cells failure may provide new insights in the treatment of T2DM.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Resistencia a la Insulina
/
Leptina
/
Diabetes Mellitus Tipo 2
/
Células Secretoras de Insulina
/
Adiponectina
/
Resistina
/
Adipoquinas
/
Metabolismo
/
Obesidad
Límite:
Humanos
Idioma:
Inglés
Revista:
Acta Academiae Medicinae Sinicae
Año:
2016
Tipo del documento:
Artículo
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