Research Advances in Pituitary Adenoma and DNA Methylation / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 475-479, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-277953
ABSTRACT
DNA methylation is closely related to the genesis and development of pituitary adenoma. Studies have shown that high methylation in the promoter region of potassium voltage-gated chanel,shaker related subfamily,beta member 2,O-6-methylguanine-DNA methyltransferase,echinoderm microtubule associated protein like 2 ,ras homolog family member D ,homeobox B1 ,NNAT, and P16 inhibits the expression of these genes and regulates of the proliferation of pituitary adenoma. DNA methylation is also closely related to invasive pituitary adenoma. Therefore,further study on molecular mechanism of DNA methylation of pituitary adenoma will offer a new strategy for the diagnosis and treatment of pituitary adenoma.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Hipofisarias
/
Adenoma
/
Regulación Neoplásica de la Expresión Génica
/
Regiones Promotoras Genéticas
/
Metilación de ADN
/
Genética
Límite:
Humanos
Idioma:
Inglés
Revista:
Acta Academiae Medicinae Sinicae
Año:
2016
Tipo del documento:
Artículo
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