Correlation analysis between WNK4 gene and essential hypertension / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 145-148, 2003.
Article
en Zh
| WPRIM
| ID: wpr-278110
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate association of mutation in WNK4 gene with essential hypertension and to analyze the expression of WNK4 gene.</p><p><b>METHODS</b>cSNP in WNK4 gene in a small samples was detected by sequencing, then PCR-RFLP was performed in 98 patients with essential hypertension and 95 control subjects. The expression profile of WNK4 gene was tested by RT-PCR.</p><p><b>RESULTS</b>A cSNP was detected in WNK4 gene exon7 G1662A, and there were significant differences in the distribution of allele frequency of G1662A between essential hypertension group and control group. WNK4 gene were expressed in the tissues of kidney, brain, lung, heart, spleen and intestine of fetus.</p><p><b>CONCLUSION</b>WNK4 gene is well correlated with essential hypertension.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Fenotipo
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Encéfalo
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ARN Mensajero
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Expresión Génica
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Proteínas Serina-Treonina Quinasas
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Predisposición Genética a la Enfermedad
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Frecuencia de los Genes
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Genes
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Genética
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Hipertensión
Límite:
Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Año:
2003
Tipo del documento:
Article