Synthesis and preliminary studies of O-(2-18F fluoroethyl)-L-tyrosine as a positron emission tomography imaging agent / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 370-372, 2002.
Artículo
en Chino
| WPRIM
| ID: wpr-278162
ABSTRACT
<p><b>OBJECTIVE</b>To develop a 18F-labeled amino acid, O-(2-[18F]fluoroethyl) - L-tyrosine(18F-FET), as a positron emission tomography (PET) tracer for imaging cerebral tumors.</p><p><b>METHODS</b>18F-FET was synthesized. Preclinical studies including sterility, endotoxin, and toxicity tests were performed. Two brain tumor cases were studied using 18F-FET and compared with 18F-FDG.</p><p><b>RESULTS</b>Radiochemical purity of 18F-FET was over 95% which remained stable for 6 hours. The 18F-FET injection was sterile and its endotoxin content accorded with the standards of Chinese Pharmacopoeia. The uptake of 18F-FET in the normal brain tissues was significantly lower than that of the tumor, and the images of the brain tumor were clearer than those of 18F-FDG.</p><p><b>CONCLUSION</b>18F-FET can accumulate in the tumor tissues to give high quality images. It suggests that 18F-FET may be a safe and effective tracer for brain tumor imaging.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sarcoma 180
/
Tirosina
/
Neoplasias Encefálicas
/
Diagnóstico por Imagen
/
Radioisótopos de Flúor
/
Tomografía Computarizada de Emisión
/
Glioblastoma
/
Fluorodesoxiglucosa F18
Tipo de estudio:
Estudio diagnóstico
Límite:
Animales
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2002
Tipo del documento:
Artículo
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