Design and synthesis of 3'-methyl-furanonucleosides and their anti-tumor activities / 药学学报
Acta Pharmaceutica Sinica
;
(12): 747-753, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-278188
ABSTRACT
Taking 3'-Me-Ado (3'-methyladenosine) and Cladribine as the leading compounds, seventeen 3'-C-methyl-furanonucleosides were designed and synthesized. All the structures were confirmed by 1H NMR and MS. The target compounds were tested in vitro against human pulmonary carcinoma A549, human colon carcinoma LOVO and human leukemia CEM by MTT assay. The results showed that these compounds possessed moderate cytotoxicities.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Ensayos de Selección de Medicamentos Antitumorales
/
Estructura Molecular
/
Adenosina
/
Cladribina
/
Línea Celular Tumoral
/
Antineoplásicos
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2009
Tipo del documento:
Artículo
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