Synthesis, solubility, lipids-lowering and liver-protection activities of sulfonated formononetin / 药学学报
Acta Pharmaceutica Sinica
; (12): 386-389, 2009.
Article
en Zh
| WPRIM
| ID: wpr-278252
Biblioteca responsable:
WPRO
ABSTRACT
A water-soluble compound, sodium formononetin-3'-sulfonate with good lipid-lowering and liver-protection activities was synthesized. It was synthesized by sulfonation reaction, and its structure was characterized by IR, NMR and elemental analyses. The solubility of sodium formononetin-3'-sulfonate in water and n-octanol/water partition coefficient were determined by UV spectrophotometry. The lipid-lowering and liver-protection activities of sodium formononetin-3'-sulfonate were tested by using rat's high fat model induce by feeding with high fat food. The results showed that sodium formononetin-3'-sulfonate not only had favorable water, solubility but also had good lipid-lowering and liver-protection activities.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Patología
/
Farmacología
/
Aspartato Aminotransferasas
/
Solubilidad
/
Triglicéridos
/
Sangre
/
Estructura Molecular
/
Química
/
Tejido Adiposo
/
Colesterol
Límite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2009
Tipo del documento:
Article