Synthesis and antibacterial activity of 7 beta-2-(2-substituted aminothiazol-4-yl)-(Z)-2-methoxyiminoacetylamido-3-quaternaryammoniummethyl-cephalosporins / 药学学报
Acta Pharmaceutica Sinica
;
(12): 366-370, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-278255
ABSTRACT
In order to find new cephalosporin with more and more potent antibacterial activity, nine new fourth-generation cephalosporins (N1-N9) were synthesized from ethyl 2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetate (1) via acylation, substitution, hydrolysis, active esterification, condensation and salt formation. The structures of compounds (N1-N9) were confirmed by IR, MS, 1H NMR and elemental analysis. The target compounds possess different antimicrobial activities against Gram-positive and Gram-negative bacteria. The preliminary results of antibacterial activities revealed that they showed better antibacterial activities against Gram-positive bacteria than cefpirome sulfate. In particular, their activities against Staphylococcus aureus and Streptococcus albus are better.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Staphylococcus aureus
/
Streptomyces
/
Estructura Molecular
/
Cefalosporinas
/
Química
/
Bacterias Gramnegativas
/
Bacterias Grampositivas
/
Antibacterianos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2009
Tipo del documento:
Artículo
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