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Removal of αGal xenotransplantation antigen by a novel α-galactosidase / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1231-1234, 2012.
Artículo en Chino | WPRIM | ID: wpr-278400
ABSTRACT
αGal, a xenotransplantations antigen (XTA), can lead to hyper acute reaction (HAR) in xenotransplantation. α-Galactosidase from B. fragilis is a novel galactosidase belong to CAZy GH110 which can clear the terminal αGal from branched and linear oligosaccharides. This study was purposed to investigate the removal effect of a novel α-galactosidase on α-Gal XTA on surface of red blood cells. The αGal XTA from the red blood cells of cattle, pig, dog and rabbit was digested by using recombinant α-galactosidase; the α-Gal antigens on surface of cells was detected by flow cytometry. The results showed that the XTA was disappeared completely or mainly. It is concluded that the novel α-galactosidase is a potential enzyme to remove the XTA on the surface of xenotransplants and can be used to overcome the HAR in xenotransplantation.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Porcinos / Trasplante Heterólogo / Antígenos Heterófilos / Alfa-Galactosidasa / Alergia e Inmunología / Eritrocitos / Macaca mulatta / Ratones Endogámicos BALB C / Epítopos Límite: Animales Idioma: Chino Revista: Journal of Experimental Hematology Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Porcinos / Trasplante Heterólogo / Antígenos Heterófilos / Alfa-Galactosidasa / Alergia e Inmunología / Eritrocitos / Macaca mulatta / Ratones Endogámicos BALB C / Epítopos Límite: Animales Idioma: Chino Revista: Journal of Experimental Hematology Año: 2012 Tipo del documento: Artículo