Expression of t(11;18) and bcl-10 in gastrointestinal MALT lymphoma / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 35-38, 2004.
Article
en Zh
| WPRIM
| ID: wpr-278806
Biblioteca responsable:
WPRO
ABSTRACT
To detect chromosome translocation t(11;18) (q21;q21) and the nuclear expression of bcl-10 in gastrointestinal mucosa-associated lymphoid tissue (MALT) lymphoma in Chinese, a possible API2-MALT fusion transcript specific to t(11; 18) (q21; q21) in tumors from 42 cases of primary gastrointestinal lymphoma (29 cases of low grade MALT lymphoma, 13 cases of transformed MALT lymphoma) and 40 cases of diffuse large B cell lymphoma was examined by means of RT-PCR and proved by DNA-sequencing. Bcl-10 expression was examined by immunohistochemical method. The results showed that t(11;18) (q21;q21) was 14% positive in cases of low grade MALT lymphomas and 46% positive in transformed MALT lymphomas, but none in cases of DLBCL. Bcl-10 nuclear expression was seen 61% in low grade MALT and 69% in transformed MALT lymphoma. It was suggested that t(11;18) (q21;q21) was related to the prognosis and development of highly advanced MALT lymphoma but not relevant to DLBCL. Bcl-10 nuclear expressions were not significantly different between these two groups, which remains to be explained.
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Índice:
WPRIM
Asunto principal:
Translocación Genética
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Cromosomas Humanos Par 11
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Cromosomas Humanos Par 18
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Inmunohistoquímica
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Proteínas Portadoras
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Núcleo Celular
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Química
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Linfoma de Células B de la Zona Marginal
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Proteínas Adaptadoras Transductoras de Señales
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Proteína 10 de la LLC-Linfoma de Células B
Límite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2004
Tipo del documento:
Article