Change of expression of cell adhesion molecules CD11a and CD49d in patients with chronic aplastic anemia before and after therapy / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 659-661, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-278818
ABSTRACT
To explore the cell adhesion molecules (CAMs) CD11a and CD49d in patients with chronic aplastic anemia (CAA) and its clinical implications, the expression of CD11a and CD49d in mononuclear cell (MNC) of bone marrow (BM) and peripheral blood (PB) were measured using APAAP techniques in 20 patients with CAA before and after SSL/C therapy. The results showed that the expression of CD11a and CD49d in MNC of BM and CD11a in MNC of PB increased significantly (P < 0.05) after SSL/C therapy, and there was no significant change of CD49d in MNC of PB in both groups. In conclusion, the decrease of CAMs of CD11a and CD49d participated in the pathogenesis of CAA. The expression of CAMs increases with effective treatment, so the restoration or improvement of altered CAMs of CAA might be beneficial to the proliferation and differentiation of hematopoietic stem cell, and improvement of hematopoiesis in CAA.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sangre
/
Recuento de Células Sanguíneas
/
Química
/
Enfermedad Crónica
/
Antígeno CD11a
/
Integrina alfa4
/
Anemia Aplásica
/
Leucocitos
Límite:
Adolescente
/
Adulto
/
Anciano
/
Niño
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2003
Tipo del documento:
Artículo
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