Discovery of the main active constituents of siwu mixture for reversing the multidrug resistance of human erythrocyte leukemic cell line K562/ADM / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 520-523, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-279123
ABSTRACT
<p><b>OBJECTIVE</b>To study the main active constituents of Siwu mixture for reversing the multidrug resistance (MDR) of human erythrocyte leukemic cell line K562/ADM.</p><p><b>METHOD</b>Macroporous resin was used to separate Siwu mixture and an in vitro model was used to evaluate the reversal index of each fraction for discovery of active fraction. HPLC-MS was used for investigating the main active constituents of Siwu mixture.</p><p><b>RESULT</b>The reversal index of the gross polysaccharide of Rehmannia glutinosa was significantly higher than that of blank control (P < 0.01). There was little difference between the reversal effect of the gross polysaccharide of Rehmannia glutinosa and that of the active fraction A (P > 0.05).</p><p><b>CONCLUSION</b>The gross polysaccharide of Rehmannia glutinosa is one of the main active constituents of Siwu mixture.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Plantas Medicinales
/
Polisacáridos
/
Medicamentos Herbarios Chinos
/
Doxorrubicina
/
Química
/
Resistencia a Múltiples Medicamentos
/
Resistencia a Antineoplásicos
/
Células K562
/
Ligusticum
Límite:
Humanos
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2005
Tipo del documento:
Artículo
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