Studies on constituents from the fermentation of Alternalia sp / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the metabolites of marine fungus Alternalia sp.</p><p><b>METHOD</b>Compounds were separated by column chromatography and their structures were elucidated by means of chemical and spectral analysis.</p><p><b>RESULT</b>Six compounds were isolated from the ethyl acetate and n-butanol extracts of the fermentation of marine fungus Alternalia sp. Their structures were elucidated as p-benzyloxy-phenol ( I ), p-hydroxy phenyl ethylamine( II ), 3-hydroxymethyl-8-hydroxyl-pyrrolopiperazine-2, 5-dione ( III ), 3-isobutyl-6-secbutyl-piperazine-2, 5-dione (IV), 5alpha, 8alpha-epidioxy-ergosta-6, 22-diene-3beta-ol (V), 3beta-hydroxxy-cholesta-5-ene (VI).</p><p><b>CONCLUSION</b>Compounds I , II, III, IV have the activity of inducing morphological deformation of mycelia germinated from conidia of Pyricularia oryzae. Compounds I , II , III were isolated from the genus Alternalia for the first time.</p>