Comparison of total phenol of magnolia solid dispersion prepared by different methods / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 4400-4405, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-279226
ABSTRACT
To compare the difference of total phenol of magnolia solid dispersion prepared by different methods. Hot melt extrusion, solvent evaporation method, and fusion-cooling method were used to prepare total phenol of Magnolia accessory solid dispersion, Plastone S-630 and HPC. The drug dispersion state in the prepared solid dispersion was evaluated with DSC and X-ray diffraction; FT-IR method was used to analyze the possible connections between drug and accessories. Finally, accelerated stability-in vivo dissolution test was use to compare the stability differences between these three processes. The results of DSC and X-ray diffraction showed that all of the drug in solid dispersion processed by three processes can exist in amorphous form; FT-IR results also could not distinguish the difference between the three processes; accelerated stability-in vivo dissolution test showed the stability of solid dispersion prepared by HPC was better than Plastone S-630, and the same kinds of materials solid dispersion prepared by hot melt extrusion showed a better stability than the other two processes.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Difracción de Rayos X
/
Medicamentos Herbarios Chinos
/
Química
/
Química Farmacéutica
/
Espectroscopía Infrarroja por Transformada de Fourier
/
Fenol
/
Magnolia
/
Métodos
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2015
Tipo del documento:
Artículo
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