Effect of ginsenoside total saponinon on regulation of P450 of livers of rats after γ-ray irradiation / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 4037-4043, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-279288
ABSTRACT
Effect of ginsenoside total saponin (GTS) on the regulation of P450 of livers of rats after γ-ray irradiation was studied. Rats were irradiated by the ⁶⁰Coγ-ray for one-time dose of 5.5 Gy, dose rate of 117.1-119.2 cGy. The cocktail probe, qPCR and Western blot were used to detect expression of enzymatic activites, mRNA and protein of rats. Contrasted with blank group, expression of CYP1A2, 2B1, 2E1, 3A4 of irradiation group showed a up-regulated (P < 0.05). Contrasted with irradiation group, exprression of CYP1A2, 2B1, 2E1, 3A4 of GTS group showed a downward trend. GTS had negative agonistic action against expression of P450 of rats by irradiatied.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Efectos de la Radiación
/
Microsomas Hepáticos
/
Medicamentos Herbarios Chinos
/
Química
/
Ratas Wistar
/
Sistema Enzimático del Citocromo P-450
/
Ginsenósidos
/
Rayos gamma
/
Genética
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2015
Tipo del documento:
Artículo
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