Effects of cholecystokinin octapeptide on rat cardiac function and the receptor mechanism / 生理学报
Acta Physiologica Sinica
;
(6): 239-243, 2002.
Artículo
en Inglés
| WPRIM
| ID: wpr-279304
ABSTRACT
The aim of this study was to explore the effects of cholecystokinin octapeptide (CCK-8) on cardiac function and the receptor mechanism in anesthetized rats. The mean arterial pressure (MAP), heart rate (HR), the left ventricle systolic pressure (LVP) and the maximal/minimum rate of LVP (+/-LV dp/dt(max)) were measured. The results obtained are as follows. (1) Low dose of CCK-8 (0. 4 microgram/kg i.v.) caused tachycardia and slight increase in MAP, LVP and LV dp/dt(max) (P<0.01), while medium dose (4.0 microgram/kg i.v.) and high dose of CCK-8 (40 microgram/kg i.v.) elicited a bradycardia and marked increase in MAP, LVP and LV dp/dtmax (P<0.01). (2) Proglumide (1.0 mg/kg i.v.), a CCK-receptor (CCK-R) antagonist, significantly inhibited the pressor effects of CCK-8, whilst it reversed the bradycardic responses (P<0.01). (3) Using reverse transcription polymerase chain reaction (RT-PCR), CCK-A receptor (CCK-AR) and CCK-B receptor (CCK-BR) mRNA were expressed in myocardium of rats. The above results indicate that CCK-8 may enhance cardiac function in a dose-dependent manner and elicit a change in HR, which is likely induced by the activation of CCK-R on myocardium.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Sincalida
/
Función Ventricular Izquierda
/
Receptores de Colecistoquinina
/
Ratas Sprague-Dawley
/
Presión Ventricular
/
Relación Dosis-Respuesta a Droga
/
Frecuencia Cardíaca
/
Metabolismo
/
Miocardio
Límite:
Animales
Idioma:
Inglés
Revista:
Acta Physiologica Sinica
Año:
2002
Tipo del documento:
Artículo
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