Nonvolatile chemical constituents from Pogostemon cablin / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the nonvolatile chemical constituents from the ethanol extract of the stems of Pogostemon cablin.</p><p><b>METHOD</b>The constituents were isolated and purified by repeated column chromatography on silica gel and Sephadex LH-20. Their structures were identified by physicochemical properties and spectroscopic analysis.</p><p><b>RESULT</b>Twelve compounds were isolated and identified as tilianin (1), diosmetin-7-O-beta-D-glucopyranoside (2), 3"-O-methylcrenatoside (3), uracil (4), soya-cerebroside I and II (5), agastachoside (6), apigenin-7-O-(3", 6"-di-(E) -p-coumaroyl) -beta-D-galactopyranoside (7), 5-hydroxy-3, 3', 4', 7- tetramethoxy flavone (8), 4', 5-dihydroxy-3, 3', 7-trimethoxyflavone (9), acacetin (10), crenatoside (11), isocrenatoside (12).</p><p><b>CONCLUSION</b>Compounds 1, 2, 4-7, 10 were isolated from the genus Pogostemon for the first time.</p>