The inhibition activity of chemical constituents in hawthorn fruit and their synergistic action to HMG-CoA reductase / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2428-2431, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-279427
ABSTRACT
<p><b>OBJECTIVE</b>To study the hypolipidemic active compounds from Crataegus pinnatifida and mechanism of action of those.</p><p><b>METHOD</b>Guided by the inhibitory activity to HMG-CoA reductase, the active compounds were separated and purified with macroporous resin and silica gel.</p><p><b>RESULT</b>Four active compounds were obtained, which were quercetin, hyperoside, rutin and chlorogenic acid, the sum of their inhibitory rate was 50.01%, and the total inhibitory rate of the mixture of four active compounds matched was 79.48%.</p><p><b>CONCLUSION</b>Quercetin and hyperoside were the principle active components inhibiting HMG-CoA reductase in Hawthorn fruit, and there were synergistic action among them.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Extractos Vegetales
/
Química
/
Inhibidores de Hidroximetilglutaril-CoA Reductasas
/
Crataegus
/
Frutas
/
Hidroximetilglutaril-CoA Reductasas
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2010
Tipo del documento:
Artículo
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