Clinical implication of surgically treated early-stage cervical cancer with multiple high-risk factors / 부인종양
Journal of Gynecologic Oncology
;
: 3-11, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-27948
ABSTRACT
OBJECTIVE:
Presence of high-risk factor in cervical cancer is known to be associated with decreased survival outcomes. However, the significance of multiple high-risk factors in early-stage cervical cancer related to survival outcomes, recurrence patterns, and treatment implications is not well elucidated.METHODS:
A retrospective study was conducted for surgically treated cervical cancer patients (stage IA2-IIB, n=540). Surgical-pathological risk factors were examined and tumors expressing > or =1 high-risk factors (nodal metastasis, parametrial involvement, or positive surgical margin) were eligible for analysis (n=177, 32.8%). Survival analysis was performed based on the number of high-risk factors and the type of adjuvant therapy.RESULTS:
There were 68 cases (38.4%) expressed multiple high-risk factors (2 high-risk factors n=58, 32.8%; 3 high-risk factors n=10, 5.6%). Multiple high-risk factors remained an independent prognosticator for decreased survival outcomes after controlling for age, histology, stage, and treatment type (disease-free survival hazard ratio [HR], 2.34; p=0.002; overall survival HR, 2.32; p=0.007). Postoperatively, 101 cases (57.1%) received concurrent chemoradiotherapy (CCRT) and 76 cases (42.9%) received radiotherapy (RT) alone. CCRT was beneficial in single high-risk factor cases HRs for CCRT over RT alone for cumulative risk of locoregional and distant recurrence, 0.27 (p=0.022) and 0.27 (p=0.005), respectively. However, tumor expressing multiple high-risk factors completely offset the benefit of CCRT over RT alone for the risk of distant recurrence HR for locoregional and distant recurrence, 0.31 (p=0.071) and 0.99 (p=0.980), respectively.CONCLUSION:
Special consideration for the significance of multiple high-risk factors merits further investigation in the management of surgically treated early-stage cervical cancer.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Análisis de Supervivencia
/
Neoplasias del Cuello Uterino
/
Estudios Retrospectivos
/
Factores de Riesgo
/
Radioterapia Adyuvante
/
Quimioradioterapia Adyuvante
/
Histerectomía
/
Metástasis Linfática
/
Recurrencia Local de Neoplasia
/
Estadificación de Neoplasias
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Journal of Gynecologic Oncology
Año:
2015
Tipo del documento:
Artículo
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