Safety and immunogenicity of split vaccines of influenza viruses / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 207-209, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-279574
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the safety and immunogenicity of influenza split vaccine.</p><p><b>METHODS</b>According to the criteria of No.2002SL0043, instruction of application for new drug in clinical trial issued by the State Food and Drug Administration, 876 healthy persons were divided at random into vaccine group and control group. The trial was performed with the double blind method. Local and systemic adverse reactions were observed within 3 days after the vaccine group subjects were vaccinated. The antibody response to vaccines was detected with hemagglutination inhibition (HI) test. Numbers of seroconversions and HI titers greater than or equal to 40, as well as the mean geometric titer increase in HI were analyzed.</p><p><b>RESULTS</b>There was no significant difference in local and systemic adverse reaction between vaccine and control groups. Meanwhile there was also no significant difference in seroconversions and protective level between two groups. However, there was obvious difference in mean geometric titer increase of antibody against H1N1 virus, while there was no significant difference in that of antibodies to H3N2 and type B viruses.</p><p><b>CONCLUSIONS</b>The safety and immunogenicity of both vaccines are excellent.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Virus de la Influenza A
/
Virus de la Influenza B
/
Seguridad
/
Sangre
/
Pruebas de Inhibición de Hemaglutinación
/
Vacunas contra la Influenza
/
Vacunas de Productos Inactivados
/
Método Doble Ciego
/
Clasificación
/
Alergia e Inmunología
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Adolescente
/
Adulto
/
Anciano
/
Niño
/
Child, preschool
/
Humanos
/
Lactante
Idioma:
Chino
Revista:
Chinese Journal of Experimental and Clinical Virology
Año:
2004
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS