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Effect of caffeine citrate on early pulmonary function in preterm infants with apnea / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 206-210, 2016.
Artículo en Chino | WPRIM | ID: wpr-279871
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of caffeine citrate treatment on early pulmonary function in preterm infants with apnea.</p><p><b>METHODS</b>Forty preterm infants with apnea were randomly divided into aminophylline treatment group (20 infants) and caffeine citrate treatment group (20 infants). When the preterm infants experienced apnea after birth, they were given aminophylline or caffeine citrate in addition to assisted ventilation with continuous positive airway pressure (NCPAP). After drug discontinuation, pulmonary function was measured and compared between the two groups.</p><p><b>RESULTS</b>After treatment, compared with the aminophylline treatment group, the caffeine citrate treatment group had significantly higher tidal volume, minute ventilation volume, ratio of time to peak tidal expiratory flow to total expiratory time, ratio of volume to peak tidal expiratory flow to total expiratory volume, peak expiratory flow, and breathing flow at 75%, 50%, and 25% of tidal volume (P<0.05). The caffeine citrate treatment group had a significantly shorter time of oxygen use and NCPAP support than the aminophylline treatment group (P<0.01). Compared with the aminophylline treatment group, the caffeine citrate treatment group had a significantly lower frequency of apnea attacks (P<0.01).</p><p><b>CONCLUSIONS</b>In the treatment of apnea in preterm infants, caffeine citrate can improve early pulmonary function and reduce the incidence of apnea.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Apnea / Farmacología / Cafeína / Recien Nacido Prematuro / Citratos / Usos Terapéuticos / Presión de las Vías Aéreas Positiva Contínua / Quimioterapia / Aminofilina / Pulmón Límite: Femenino / Humanos / Masculino / Recién Nacido Idioma: Chino Revista: Chinese Journal of Contemporary Pediatrics Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Apnea / Farmacología / Cafeína / Recien Nacido Prematuro / Citratos / Usos Terapéuticos / Presión de las Vías Aéreas Positiva Contínua / Quimioterapia / Aminofilina / Pulmón Límite: Femenino / Humanos / Masculino / Recién Nacido Idioma: Chino Revista: Chinese Journal of Contemporary Pediatrics Año: 2016 Tipo del documento: Artículo