Detection of subtelomeric copy number variations in children with intellectual disability / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1273-1276, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-279927
ABSTRACT
<p><b>OBJECTIVE</b>To detect subtelomeric copy number variations in children with genetic intellectual disability (ID) using multiplex ligation-dependent probe amplification (MLPA), and to investigate the pathogenesis of genetic ID.</p><p><b>METHODS</b>A total of 68 children with ID who had normal results of G-banding karyotype analysis were included in the study. Their subtelomeric copy number variations were detected using MLPA P036.</p><p><b>RESULTS</b>Among the 68 children with ID, 7(10%) showed subtelomeric copy number variations, and all the variations were deletion mutations. Among them, 1 case carried 2 subtelomeric microdeletions, and 1 case carried 4 subtelomeric microdeletions.</p><p><b>CONCLUSIONS</b>Subtelomeric copy number variations are important causes of genetic ID. MLPA can be used as an economic and effective method for investigating the pathogenesis of genetic ID.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Telómero
/
Variaciones en el Número de Copia de ADN
/
Reacción en Cadena de la Polimerasa Multiplex
/
Genética
/
Discapacidad Intelectual
Tipo de estudio:
Estudio diagnóstico
Límite:
Adolescente
/
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Lactante
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2015
Tipo del documento:
Artículo
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