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Association between the polymorphism of HLA-DQA1 alleles and type 2 diabetes in Yi nationality of Yunnan / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 702-704, 2005.
Artículo en Chino | WPRIM | ID: wpr-279963
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between the polymorphism of HLA-DQA1 alleles and type 2 diabetes in Yi nationality of Yunnan.</p><p><b>METHODS</b>Polymerase chain reaction with sequence-specific primers (PCR-SSP) genotyping method was conducted in 58 ethnic Yi patients with type 2 diabetes mellitus and 82 ethnically matched controls from Chuxiong of Yunnan. Then a study was made on the association between the polymorphism of HLA-DQA1 alleles and type 2 diabetes mellitus.</p><p><b>RESULTS</b>The frequency of HLA-DQA1*0301 allele in the patients with type 2 diabetes mellitus was significantly higher than that in the healthy controls (P=0.002, RR=3.097), and the frequency of HLA-DQA1*0601 in the patients was significantly lower (P=0.025, RR=0.429).</p><p><b>CONCLUSION</b>In Yi nationality of Yunnan, HLA-DQA1*0301 allele may be a susceptible gene and the HLA-DQA1*0601 allele may protect individuals from the risk of diabetes mellitus.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Polimorfismo Genético / Antígenos HLA-DQ / China / Reacción en Cadena de la Polimerasa / Predisposición Genética a la Enfermedad / Diabetes Mellitus Tipo 2 / Cadenas alfa de HLA-DQ / Genética Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Chino Revista: Chinese Journal of Medical Genetics Año: 2005 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Polimorfismo Genético / Antígenos HLA-DQ / China / Reacción en Cadena de la Polimerasa / Predisposición Genética a la Enfermedad / Diabetes Mellitus Tipo 2 / Cadenas alfa de HLA-DQ / Genética Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Chino Revista: Chinese Journal of Medical Genetics Año: 2005 Tipo del documento: Artículo