Association study of sleep apnea syndrome and polymorphisms in the serotonin transporter gene / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 533-536, 2005.
Article
en Zh
| WPRIM
| ID: wpr-280008
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To identify polymorphisms of the serotonin transporter(5-HTT) gene and to find out whether there was relationship between any such polymorphisms and sleep apnea syndrome (SAS).</p><p><b>METHODS</b>For two polymorphisms of 5-HTT target DNA gene was amplified using polymerase chain reaction (PCR) and 6% non-denaturing polyacrylamide gels electrophoresis. The frequencies of the different forms of the genotypes and alleles of 5-HTT gene were analyzed in 104 patients with SAS and 150 healthy controls.</p><p><b>RESULTS</b>The frequencies of the S or L alleles and the S/S, S/L or L/L genotypes in promoter region of 5-HTT gene in SAS group were not significantly different to those in healthy controls (P > 0.05). However, the frequencies of 10/10, 12/10 genotypes of 5-HTT-VNTR in SAS patients were significantly higher than those in healthy control subjects (P < 0.05). Moreover, the frequency of the allele 10 of 5-HTT-VNTR in SAS patients was significantly higher than that in healthy controls (P<0.01).</p><p><b>CONCLUSION</b>The allele 10 of 5-HTT-VNTR might be a susceptible factor in the pathogenesis of SAS.</p>
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Índice:
WPRIM
Asunto principal:
Polimorfismo Genético
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Síndromes de la Apnea del Sueño
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Reacción en Cadena de la Polimerasa
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Regiones Promotoras Genéticas
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Repeticiones de Minisatélite
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Predisposición Genética a la Enfermedad
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Alelos
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Proteínas de Transporte de Serotonina en la Membrana Plasmática
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Frecuencia de los Genes
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Genética
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Año:
2005
Tipo del documento:
Article