Distribution of genotype and allele frequencies of dopamine D4 receptor gene 48 bp variable number tandem repeat polymorphism in Chinese Han population in Hunan / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 470-472, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-280022
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the distribution of genotype and allele frequencies of the dopamine D4 receptor(DRD4) gene exon 3 48 bp variable number of tandem repeats polymorphism in Hunan Han population.</p><p><b>METHODS</b>The genotype and alleles of 304 healthy persons were examined with polymerase chain reaction, denaturing polyacrylamide gel electrophoresis and silver staining.</p><p><b>RESULTS</b>Seven alleles and twelve genotypes were found. The most common allele was allele 5 with a frequency of 70.6%. There was statistically significant difference in allele distribution between the Hunan Han population and the Han population of other regions such as Shanghai, Beijing and Sichuan in China (P< 0.05). Different allele frequency distributions were observed when compared to other ethnic populations such as Japanese, American, Mexican, and Italian (P< 0.05).</p><p><b>CONCLUSION</b>The distributions of allele of DRD4 gene exhibit regional and ethnic heterogeneity.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
China
/
Reacción en Cadena de la Polimerasa
/
Repeticiones de Minisatélite
/
Pueblo Asiatico
/
Receptores de Dopamina D4
/
Frecuencia de los Genes
/
Genética
/
Genotipo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2005
Tipo del documento:
Artículo
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