Transmission disequilibrium analysis of 1137-1140 Del GTGA frameshift mutation within the KCNN3 gene and schizophrenia based on family trios / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 441-443, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-280031
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between 1137-1140 Del GTGA in exon 1 at KCNN3 gene and schizophrenia.</p><p><b>METHODS</b>The study included 289 subjects (affected 107; unaffected 182) from 95 schizophrenic trios. All subjects were collected from Han Chinese in south China and genotyped for 1137-1140 Del GTGA in KCNN3 using PCR and restriction endonuclease Dde I. All the affected patients met the CCMD-II-R criteria for schizophrenia. The haplotype-based haplotype relative risk(HHRR) and transmission/disequilibrium test(TDT) analyses were done in 95 schizophrenic trios.</p><p><b>RESULTS</b>Comparative analysis on the distribution of alleles between the affected and unaffected parents(87 family trios) showed no significant difference(X(2)=0.253, P> 0.05). HHRR showed that KCNN3 gene alleles transmitted to the patients were not different from that of the non-transmitted parental alleles(X(2)=0.042, P> 0.05). TDT revealed that A(2) alleles were not preferentially transmitted to schizophrenic patients(X(2)=3.000, P=0.0833).</p><p><b>CONCLUSION</b>In this study a lower frequency for 1137-1140 Del homozygote of KCNN3 gene was observed, and the HHRR and TDT analyses suggested that the 1137-1140 Del alleles of KCNN3 gene be unlikely to confer susceptibility to schizophrenia.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Esquizofrenia
/
Haplotipos
/
Núcleo Familiar
/
Desequilibrio de Ligamiento
/
Salud de la Familia
/
Mutación del Sistema de Lectura
/
Predisposición Genética a la Enfermedad
/
Canales de Potasio de Pequeña Conductancia Activados por el Calcio
/
Genética
Tipo de estudio:
Estudio de etiología
Límite:
Adolescente
/
Adulto
/
Anciano
/
Niño
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2005
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS