P53 protein expression and chemosensitivity to cisplatin in patients with non-small cell lung cancer: a meta-analysis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 770-773, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-280099
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relation between p53 protein expression and chemosensitivity to cisplatin in patients with non-small cell lung cancer (NSCLC).</p><p><b>METHODS</b>The DerSimonian-Laird random effect model was used to analyze the data reported in relevant literature.</p><p><b>RESULTS</b>Sixteen trials involving 1070 patients were retrieved. The overall positivity rate of p53 was 50.4% and overall response rate to cisplatin was 38.7%. The test for heterogeneity showed that all eligible studies had heterogeneity (chi 2-/+47.57, P<0.0001). The combined odds ratio (OR) was 1.37, with 95% confidence interval of 0.84-2.24.</p><p><b>CONCLUSION</b>Expression of p53 protein in patients with NSCLC is not associated with the chemosensitivity to cisplatin.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Ensayos Clínicos como Asunto
/
Proteína p53 Supresora de Tumor
/
Cisplatino
/
Carcinoma de Pulmón de Células no Pequeñas
/
Resistencia a Antineoplásicos
/
Usos Terapéuticos
/
Quimioterapia
/
Neoplasias Pulmonares
/
Metabolismo
Tipo de estudio:
Revisiones Sistemáticas Evaluadas
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2008
Tipo del documento:
Artículo
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