Preliminary study of a universal vaccine based on the HA2 protein of the H5N1 influenza virus / 病毒学报
Chinese Journal of Virology
; (6): 521-528, 2014.
Article
en Zh
| WPRIM
| ID: wpr-280333
Biblioteca responsable:
WPRO
ABSTRACT
Fragments encoding amino acids 76-130 in the linear conserved region (LCR) of A/Hubei/1/2010 (H5N1) HA2 was fused to hepatitis B core antigen (HBc) to generate a LCR-HBe virus-like particle (VLP). Results showed that the fusion protein of LCR-HBc was highly expressed in this prokaryotic expression system. The purified LCR-HBc particle stimulated high levels of IgG production in mice with a titer of > 1:12 800, and provided 50% cross-protection against lethal challenge by H1N1 viruses.
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Índice:
WPRIM
Asunto principal:
Patología
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Datos de Secuencia Molecular
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Vacunas contra la Influenza
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Secuencia de Aminoácidos
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Interferón gamma
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Glicoproteínas Hemaglutininas del Virus de la Influenza
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Alergia e Inmunología
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Subtipo H5N1 del Virus de la Influenza A
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Pulmón
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Ratones Endogámicos BALB C
Límite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Virology
Año:
2014
Tipo del documento:
Article